Xanthine Oxidase

Related Products

Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.

Xanthine Oxidase Inhibitors (59)

Xanthine Oxidase Related Products (60)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N8600

7,8,3′,4′-Tetrahydroxyflavone	Inhibitor	≥99.0%
7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 10.488 µM.

HY-153968

URAT1&XO inhibitor 1	Inhibitor	99.56%
URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC₅₀=~10 μM) and Xanthine Oxidase (IC₅₀=1.01 μM). URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research.

HY-B0219A

Allopurinol sodium	Inhibitor	99.76%
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

HY-W008550

8-Azaadenine	Inhibitor
8-Azaadenine is a Xanthine Oxidase inhibitor (IC₅₀ = 0.54 μM).

HY-14268A

Febuxostat sodium	Inhibitor
Febuxostat (TEI 6720) sodium is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout.

HY-146273

Xanthine oxidase-IN-7	Inhibitor
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active XO (xanthine oxidase) inhibitor with an IC₅₀ of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout.

HY-151975

Xanthine oxidoreductase-IN-5	Inhibitor
Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia.

HY-150257A

Xanthine oxidase-IN-11	Inhibitor
Xanthine oxidase-IN-11 (XO8 analog) is an xanthine oxidase (XO) inhibitor.

HY-146297

Xanthine oxidoreductase-IN-2	Inhibitor
Xanthine oxidoreductase-IN-2 (Compound IVa) is a xanthine oxidoreductase (XOR) inhibitor with the IC₅₀ of 7.2 nM. Xanthine oxidoreductase-IN-2 shows hypouricemic effects in mice.

HY-14874S

Topiroxostat-d₄	Inhibitor
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].

HY-155123

Antioxidant agent-13	Inhibitor
Antioxidant agent-13 (Compound 5f) is an antioxidant agent. Antioxidant agent-13 inhibits DPPH and FRAP with IC₅₀s of 80.33 and 85.69 μM. Antioxidant agent-13 also inhibits LOX and XO enzymes with IC₅₀s of 16.85 and 23.01 μM.

HY-116433

Nequinate	Inhibitor
Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.

HY-N9324

Ilexoside O	Inhibitor
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC₅₀=53.05 μM).

HY-129889

Febuxostat acyl glucuronide	Inhibitor
Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor.

HY-N3906

Fraxamoside	Inhibitor
Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM.

HY-N10863

Aurantiamide benzoate	Inhibitor
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM.

HY-14268S

Febuxostat-d₉	Inhibitor	≥98.0%
Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-151973

Xanthine oxidoreductase-IN-3	Inhibitor
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.

HY-144456

Xanthine oxidase-IN-5	Inhibitor
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC₅₀ value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model.

HY-14268S1

Febuxostat-d₇	Inhibitor
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

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Xanthine Oxidase

Xanthine Oxidase

Xanthine Oxidase Related Products (60)

Antibodies (1)

Xanthine Oxidase Related Products (60):